Monday, August 24, 2020

anti body serum...back to the future

https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/donate-covid-19-plasma

Using serum of people eho recovered from a diease is an old treatment but  still used once in awhile.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274962/

For example, rabies is a big problem here in the Philippines... if you get bitten here by a strange dog, you get one injection of rabies immune globulin, and then 3 shots of rabies vaccine.

https://www.mayoclinic.org/drugs-supplements/rabies-immune-globulin-intramuscular-route/description/drg-20065738

More here
https://www.drugs.com/drug-class/immune-globulins.html

Remeber Balto and the race to Nome to bring serum to save kids from diphtheria? In the past, they manufactured it using horses, who produced lots of immune globulin, but allergy deaths were a problem. 

The covid trestment being proposed will use serum from recovered patients. You give blood, and they separate the plasma and give you your red blood cells back. Then they separate the immune globulin from the other proteins and give it to very sick patients. 

There is a risk for transmission of donor disease but screening lowers this risk.

As fot using animals to produce the product, which would loeer the cost and increase the amount available, it is too soon to say anything.

But there is a very preliminary study using  the animals technique here

https://clinicaltrials.gov/ct2/show/NCT04514302

So right now they will use serum from folks who have recovered, so there may only be enough for very sick people.

https://clinicaltrials.gov/ct2/show/NCT04514302

And of course, the usual suspects are shouting Trump is politicizing another treatment.

https://nymag.com/intelligencer/2020/08/scientists-concerned-over-trumps-new-covid-plasma-treatment.html

Because political correctness/TDS uber alles

This is the same folks who delayed testing for weeks because of accuracy issues, and who are stopping the use of HCQ, and other possible cures because of a low danger of side efects and because the medicines only lowered the mortality  a moderate degree and were often used late in the disease and didn't work unless given early.



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